Improve Wrinkles and Acne Scars with Juvgen (JUVGEN) | Thorough Explanation by an Accredited Training Facility

LIVELY CLINIC is a medical institution officially accredited by the developer of Juvgen. In addition to our written explanation, Dr. Sakata explains the mechanism clearly in a video, so please watch that as well.

LIVELY CLINIC is officially accredited by Jin Plastic Surgery in Seoul, Korea, the developer of Juvgen. Our medical director received direct training at the developer’s clinic and provides the techniques cultivated there in Japan.
Because Juvgen is a delicate treatment that regenerates the patient’s own tissue, the physician’s experience in determining injection depth and volume affects the result. We have accumulated cases since the early stage of Juvgen’s introduction in Japan, and our medical director has been involved in education and clinical research as an international KOL (Key Opinion Leader).
Being able to receive treatment in an environment closely connected to the developer’s expertise can provide considerable reassurance.

LIVELY CLINIC is also an officially accredited training facility for Juvgen. Formal training at an accredited training facility is required to introduce Juvgen in Japan. Led by our medical director, we hold study sessions and practical training for physicians and medical professionals, sharing correct theories and techniques throughout Japan. We also share the procedural standards used in training within the clinic and apply them to daily treatment.

Juvgen (JUVGEN) Autologous Dermal Regeneration is an advanced cosmetic medical technology patented in Korea. Using an ultra-fine needle, carbon dioxide gas and hyaluronic acid are repeatedly injected into the dermal layer beneath depressed areas. This treatment promotes the production of large amounts of collagen fiber tissue, creating new skin and elevating depressed areas.

Unlike conventional treatments, it does not directly treat the skin surface, making its high safety one of its defining features. The collagen tissue newly created within the dermal layer is maintained permanently, and the fact that regular maintenance is not required can also be considered a significant benefit. Results vary from person to person, but in many cases the final result is enhanced through one to three treatments.
The devices and products used for Juvgen had not received approval under Japan’s Pharmaceuticals and Medical Devices Act as of 2026. Please understand in advance that this is elective medical treatment performed under a physician’s responsibility and is not covered by public health insurance.

To understand the effects of Juvgen, it is important to know the mechanism of collagen production in the dermal layer. The injected carbon dioxide gas and hyaluronic acid stimulate the dermal layer and promote activation of fibroblasts. Activated fibroblasts produce large amounts of collagen and elastin, forming new skin tissue.

This series of processes uses the body’s natural wound-healing response, drawing out the patient’s own regenerative ability without relying on artificial substances. Because the generated collagen tissue becomes established as part of the body, the risk of foreign-body and allergic reactions is extremely low, making this a highly safe treatment. Collagen gradually matures over approximately 3 months after injection, and the skin changes toward a natural, beautiful quality.

Juvgen Autologous Dermal Regeneration is a highly versatile treatment that can address a variety of skin concerns. The conditions for which effects are particularly expected are as follows.

Let’s take a closer look at each.

Although nasolabial folds deepen with age, they are one of the conditions that may be improved with Juvgen. Compared with conventional Hyaluronic Acid Injection, it provides a more natural and longer-lasting improvement. Hyaluronic acid is absorbed over time. However, because the collagen tissue generated by Juvgen is maintained permanently, it may help maintain a youthful appearance over the long term.

Nasolabial folds are caused by a combination of skin laxity and weakening muscles, but Juvgen adds volume from inside the skin to create a natural rejuvenating effect around the mouth. It can maintain natural expressions both when the face is at rest and when smiling, making it appealing to those seeking cosmetic benefits without others noticing.

Juvgen is also effective for crater-like depressions caused by acne scars. It shows particularly strong effects for deep ice-pick and boxcar acne scars that reach the dermal layer. Even severe crater scars that previously required 10 or more laser treatments may show clear improvement with 1–2 Juvgen treatments.

Laser treatment can take only a superficial approach, whereas Juvgen directly repairs the defect in the dermal layer, the fundamental cause of the depression, so more reliable and longer-lasting improvement may be expected. After treatment, unevenness may become less noticeable and the skin may regain a smooth, beautiful quality. Many patients have reported that makeup applies significantly better and that they feel freed from their concerns.

Horizontal forehead lines are deep wrinkles formed by aging and contraction of the facial muscles, and have traditionally been considered difficult to improve. Botox can only stop the movement of the facial muscles. Juvgen, however, directly generates collagen in the dermal layer to fundamentally improve the wrinkles themselves.

Because the forehead skin is relatively thick, it is a site where the effects of Juvgen may be particularly pronounced. You may be able to regain a smooth, youthful forehead while maintaining natural expressions.

Juvgen is also effective for prominent wrinkles across the face, including marionette lines extending downward from the corners of the mouth and deep crow’s feet. Because these wrinkles form through changes in the deeper structures of the skin, superficial treatments have limitations.

Juvgen (JUVGEN) Autologous Dermal Regeneration provides a comprehensive rejuvenating effect across the face through regeneration from the dermal layer. Multiple wrinkles can be improved at the same time with one treatment, and a natural, beautiful result may be expected. It may help achieve beautiful skin that does not appear affected by age without sacrificing expressive facial movement.

Juvgen also produces significant effects for surgical scars, scars caused by trauma, and particularly depressed scar tissue. Although scar treatment has traditionally been considered extremely difficult, a regenerative approach from the dermal layer may improve scars to a less noticeable condition. Even old scars may show substantial improvement with appropriate treatment.

However, results vary from person to person depending on the type and depth of the scar and the time since it formed, so an examination beforehand is important for determining suitability. It is not indicated for raised scars such as keloids or hypertrophic scars, but may be considered highly effective for depressed scars.

Juvgen is chosen among the many available treatments for three reasons: durability, naturalness, and reliability. It is not merely a new treatment; because these qualities come together, it may be a realistic option for people with deep concerns.
Let’s look at these reasons one by one.

One appeal of Juvgen is that its effects may be maintained over time. Unlike substances such as hyaluronic acid that are absorbed and disappear from the body, the generated collagen tissue becomes established as part of your own dermis. As a result, it is said to require less frequent maintenance than treatments involving repeated injections.
Because the treatment changes the foundation itself, it creates a process in which skin quality changes rather than producing only a temporary change. However, it cannot stop natural age-related changes, so it is realistic to consider combining it with overall skin care over the course of several years.

Another reason Juvgen is supported is that it does not create shape using a foreign substance. With Hyaluronic Acid Injection, unnatural volume may develop depending on the amount and treatment site.
Juvgen instead draws out the skin’s own regenerative capacity, making excessive fullness less likely and producing a more natural-looking impression. It may aim for a well-integrated change even in areas with significant facial movement. For people who do not want others to notice their treatment, this natural quality can provide considerable reassurance.

Juvgen is a technique developed by Dr. Jin Se-hoon, director of Jin Plastic Surgery in Korea, which specializes in treating wrinkles and scars. As a pioneer in autologous dermal regeneration, he is said to have accumulated approximately 15 years and several thousand procedures in this field.
The technique has been patented in the United States and published as a cover paper in international academic journals of cosmetic surgery. According to the developer, it has also been featured on Korean public broadcasting. These patents, papers, and accumulated cases provide support for the experience behind the treatment.

To understand the features of Juvgen, it is important to know how it differs from existing treatments. Please compare it with the major treatment options so that you can receive the treatment appropriate for you.

Hyaluronic Acid Injection takes effect immediately, and results can be felt right after treatment. However, because it is absorbed in approximately 6 months to 1 year, regular additional injections are necessary. Juvgen, on the other hand, takes 2–3 months for its effects to appear, but the collagen tissue that forms is maintained permanently.

Hyaluronic Acid Injection is suitable for superficial volume enhancement, while Juvgen is superior for deep depressions and fundamental improvement of skin quality. Because hyaluronic acid is a foreign substance, there are rare risks such as allergic reactions and vascular occlusion. Since Juvgen involves regeneration of the patient’s own tissue, these risks are extremely low, which is another significant advantage.

Subcision is a treatment used for acne scars that cuts through scar tissue with a needle or specialized instrument. It aims to improve depressions by mechanically separating the tissue, but new tissue formation cannot be expected. Juvgen, by contrast, promotes active collagen production at the same time as tissue separation, so more reliable and longer-lasting improvement may be expected.

Subcision is relatively invasive, and postoperative swelling and pain tend to be more pronounced, with a longer period of downtime. Juvgen is minimally invasive and can be performed while minimizing the impact on daily life.

Trifill PRO is a type of dermal regeneration treatment developed in Korea and, like Juvgen, uses carbon dioxide gas (CO₂). The two treatments share basic principles, but differ in the products used and the injection method. Trifill PRO is primarily intended to separate scar tissue such as acne scars, and is characterized by the relatively large amount of product and gas injected per treatment.

Juvgen, by contrast, promotes natural collagen production by injecting smaller amounts of product and gas in a precise manner. It is said to be more likely to produce a smooth, natural-looking result. Juvgen is also an original technology patented in Korea, and the practitioner’s skill and experience have a significant impact on treatment results, making it important to choose a trustworthy clinic.

Growth factor treatment promotes collagen production by injecting growth factors, and its direction of action is quite similar to that of Juvgen. Both treatments produce effects over 3–6 months and share the goal of long-term durability.
The major difference is the ingredients used. Growth factor treatment does not use hyaluronic acid, so it is considered easier to avoid theoretical risks related to blood vessels. However, the possibility of lumps or unevenness is not zero. It is not a simple matter of one being superior; the suitable treatment varies depending on the condition of the skin and the concern. It is advisable to confirm the characteristics of both treatments during a consultation before choosing.

The treatment process for receiving safe and effective Juvgen treatment is as follows.

1. Consultation
2. Application of anesthetic cream
3. Treatment
4. Aftercare and follow-up

Be sure to understand the important points at each stage.

A detailed consultation with a specialist is always conducted before treatment. The skin is carefully examined, and the depth and extent of the depression are accurately measured before an optimal treatment plan is developed according to the patient’s wishes and budget. Photographs are taken to record the condition before treatment and may also allow comparison and evaluation of the effects.

During the consultation, the benefits as well as the risks and precautions of treatment are explained fully, with consideration given to enabling the patient to make an informed choice. There is no pressure to undergo treatment, and the clinic can suggest the most suitable option, including comparison with other treatments.

To reduce pain, topical anesthetic cream is applied approximately 30 minutes before treatment.

On the day of treatment, after topical anesthesia, the product is injected into the treatment area using an ultra-fine needle. Injections are performed in stages, proceeding carefully while adjusting the appropriate depth and amount. Treatment time varies depending on the area treated, but generally takes 15–20 minutes.

Pain varies from person to person, but is significantly reduced by topical anesthesia, and many people report that it is tolerable. After injection, gauze is applied to the treatment area to protect it appropriately. Walking and light daily activities are possible immediately after treatment, but strenuous exercise and alcohol should be avoided.

The following aftercare is provided after treatment.

1. Icing
　Cooling the skin immediately after treatment with a cooling pack or similar item helps reduce inflammation. This can help suppress redness and swelling.

2. Skin care
　Use gentle skin care products centered on moisturizing ingredients.

3. Sun protection
　Because the skin is delicate after treatment, thorough protection from ultraviolet rays is necessary.

4. Treatment frequency
　Fine, red, raised marks resembling small welts may persist for approximately 1 month in some cases, so treatment every 2–3 months is recommended.

Many clinics also conduct follow-up between 1 week and 1 month after treatment to check how the effects feel and the condition of the skin, adjusting the plan for the next treatment as needed. If you notice any concerning symptoms, please consult the clinic promptly.

The greatest feature of Juvgen is that it combines effects that can be felt immediately after treatment with effects that last over the long term. After the first treatment, many patients can feel an improvement in depressions within 1 week, and the final result is reached over 3–6 months.

Because the generated collagen tissue becomes established as the patient’s own tissue, it is basically maintained semi-permanently. Unlike Hyaluronic Acid Injection, regular additional treatment is not necessary, and beautiful skin may be maintained over the long term after one treatment. However, natural aging continues, and some people request additional treatment several years later.

Treatment effects vary from person to person, and results differ depending on skin quality, age, and the severity of the condition. Younger people and those with mild symptoms may expect sufficient improvement from one treatment, while approximately three treatments may be recommended for severe symptoms, so caution is necessary.

Although this is a highly safe treatment, there are risks and precautions you should know before treatment.

With an appropriate understanding, you can receive treatment with greater peace of mind.

Juvgen is a relatively safe treatment, but temporary side effects may appear after treatment. The most common are redness and swelling at the treatment site, which are normal reactions to the injections. Mild bruising may also occur for approximately 1–3 weeks, but results vary from person to person.

These symptoms improve naturally and are generally mild enough to be sufficiently covered with heavier makeup or concealer. If you have an important event coming up, adjusting the timing of treatment is recommended. Pain varies from person to person, but should generally be manageable with over-the-counter pain medication.

Although extremely rare, complications such as infection or an excessive tissue reaction may occur. Appropriate treatment techniques and postoperative care can minimize these risks, but they cannot be reduced to zero. Serious complications such as vascular occlusion and skin necrosis caused by accidental injection into a blood vessel have also been reported.

Treatment by a specialist with extensive experience and advanced technical skill is essential to prevent complications. If you notice anything unusual, it is important to contact the clinic promptly and receive appropriate care. Trustworthy clinics often have a 24-hour contact system in place.

Not everyone can receive Juvgen treatment. If any of the following conditions apply, you may not be able to receive Juvgen treatment.

If you have allergies or have experienced problems with cosmetic treatment in the past, it is important to consult a physician beforehand. A detailed medical history and examination are conducted during the consultation to carefully determine whether treatment is appropriate. Safety is given top priority, and a reasonable treatment plan is proposed.

Our doctor, Dr. Hayashi, also answers frequently asked questions in a video. We have summarized the video content in text as well, so please review both.

Juvgen can address wrinkles across the face, including nasolabial folds, marionette lines, deep forehead and glabellar wrinkles, and crow’s feet. It is also used for acne-scar depressions and depressed scars caused by surgery or trauma. Concerns involving depressions or grooves are the primary targets.
On the other hand, it may not be suitable for raised keloids or concerns primarily involving sagging. The most reliable way to determine whether your symptoms are suitable is to have them assessed during an examination.

Redness and swelling occur at the injection sites after treatment. Typical downtime is approximately 1–2 weeks, mainly involving redness and mild bruising. However, this varies depending on the treatment area and individual constitution, and fine redness may remain for approximately 1 month in some cases.
In most cases, these symptoms can be covered with makeup. If you have an important event, planning it approximately 3 weeks after treatment can provide reassurance. We will explain precautions for daily activities in detail after treatment.

Because the generated collagen tissue becomes established as your own tissue, it is said that long-term maintenance may be expected. Regular additional injections are basically not necessary, unlike with hyaluronic acid.
However, it cannot stop natural age-related changes, so please note that this does not mean you will remain unchanged for life. Some people choose additional treatment several years later according to their condition. How long the effects are perceived to last varies from person to person.

Pain varies from person to person, but the burden is greatly reduced because topical anesthetic cream is applied before treatment. You may feel a prickling sensation or slight pressure during injection, but it should generally be tolerable. In cases of strong anxiety about pain, nitrous oxide sedation may also be used. If you have any concerns, please feel free to mention them during the consultation.

In rare cases, you may feel a temporary lump at the injection site. It generally settles over time, but the depth and amount of injection affect the result, making the physician’s skill important.
Unlike hyaluronic acid, Juvgen is not a treatment that can easily be reversed with a dissolving agent. For this reason, receiving treatment from an experienced physician is important for reducing the risk of lumps. If concerning symptoms persist, please consult us promptly.

Juvgen is a minimally invasive treatment that promotes regeneration of the patient’s own tissue, and the risks of foreign-body and allergic reactions are considered relatively low. However, this does not mean that there are no risks at all.
The devices and products used for Juvgen have not been officially approved in Japan, and the treatment is elective medical care performed under a physician’s responsibility. It is not covered by public health insurance, and results and progress vary from person to person. After understanding these conditions, it is important to choose a trustworthy medical institution.

Because Juvgen uses hyaluronic acid, impaired blood flow caused by accidental injection into a blood vessel exists as a theoretical risk. It is also a fact that serious complications such as vascular occlusion and skin necrosis have been reported depending on the condition of the skin.
To avoid these risks, it is essential that a physician familiar with the course of blood vessels determine the appropriate layer and amount before performing the treatment. If you experience severe pain or a change in skin color after treatment, contact the clinic promptly.

Juvgen Autologous Dermal Regeneration is an innovative treatment that may produce groundbreaking effects for deep acne scars, scars, and nasolabial folds that have been difficult to improve with conventional treatments. Its greatest appeal may be that it promotes fundamental regeneration from the dermal layer, allowing natural, long-lasting improvement to be expected.

When considering treatment, it is important to receive a careful consultation with a specialist who has extensive experience and technical expertise, and to develop a treatment plan suited to your symptoms and wishes. Understand the risks and precautions fully, then receive treatment safely at a trustworthy clinic. As the first step toward beautiful skin, Juvgen may be a treatment that offers hope to many people.

LIVELY CLINIC is an educational facility officially accredited by the developer of Juvgen. Led by our medical director, we conduct educational activities to pass on correct theories and techniques throughout Japan, including study sessions and practical training for physicians and medical professionals. By sharing clinical knowledge and case data, we have also worked to improve treatment precision and reduce the risk of side effects.

As a facility that provides education, we value “delivering the best possible result for our customers.” Is Juvgen suitable for your concern? How many treatments might be needed? The quickest way to answer these questions is to have your skin examined in person. We offer free consultations, so please feel free to contact us first. It is currently offered at the Hamamatsucho and Osaka branches.

LIVELY CLINIC introduced Juvgen (Autologous Dermal Regeneration) to Japan at an early stage and has an extensive record of treatments and cases in the field of skin regeneration.
Because we have addressed the concerns of many patients and accumulated experience, we can respond flexibly to a wide range of concerns.
We also regularly share the latest case photos and treatment progress on our official Instagram.
Through actual cases, you can appreciate the potential of Juvgen as regenerative medicine and LIVELY CLINIC’s commitment to “natural, beautiful results.”
If you are interested, please visit our official Instagram.