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Can Rejuran Improve Under-Eye Dark Circles and Wrinkles?

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  • Can Rejuran Improve Under-Eye Dark Circles and Wrinkles?

The appearance of the eyes can greatly influence how a person is perceived. As a result, under-eye dark circles tend to create an impression of “tiredness,” while wrinkles can give an impression of “aging.”

For those concerned about these types of eye-area issues, we would like to introduce Rejuran as one possible approach.

Rejuran is a product expected to help improve under-eye dark circles and wrinkles. Here, after explaining the causes of under-eye dark circles and wrinkles, we will discuss the effects that can be expected from Rejuran.

At the end of this article, we will also introduce Rapunzel Injection, our original treatment combining high-concentration salmon (Rejuran) with other beauty ingredients.

Contents

What Is Rejuran?

Rejuran is a product whose main ingredient is the beauty ingredient polynucleotide, derived from salmon, and it is used for treatment at cosmetic medical clinics and similar facilities.

By acting on skin cells, polynucleotide is expected to offer significant cosmetic benefits, repairing age-related deterioration such as wrinkles, spots, and sagging, and regenerating youthful, firm skin.

Rejuran can also be used on a wide range of areas where skin deterioration is a concern, including the face, neck, and backs of the hands. It is also used to treat thin areas of skin such as under the eyes.

What Causes Under-Eye Dark Circles and Wrinkles?

Under-eye dark circles and wrinkles tend to create a gloomy impression of fatigue or aging. What causes these dark circles and wrinkles to appear?

Age-Related Decline

Under-eye dark circles and wrinkles become more likely to appear as we age.

Collagen and elastin are needed to maintain firm, resilient skin, and they are produced through the activity of fibroblasts. Fibroblasts decrease rapidly from around the age of 40, and collagen and elastin also decline accordingly. This makes wrinkles and sagging more likely to develop.

The skin under the eyes is particularly thin and susceptible to damage, and it is also an area where the effects of age-related wrinkles and sagging are likely to become noticeable.

Dryness Caused by Insufficient Skin Moisture

Dry skin can cause wrinkles and make dark circles more noticeable.

Because there is less sweat and sebum production around the eyes, it is more difficult to retain moisture in this area than in other areas, making it susceptible to dryness. Insufficient moisture in the skin can also cause a loss of firmness, texture, and elasticity. As a result, dark circles and wrinkles become more noticeable when the skin lacks moisture.

The following measures can help prevent dry skin.

  • Be careful of cold and dryness caused by air conditioning and heating
  • Perform skincare thoroughly while avoiding unnecessary strain on the skin
  • Get sufficient sleep
  • Aim for a well-balanced diet

Damage Caused by UV Rays

UV rays can also cause skin sagging, leading to under-eye dark circles and wrinkles.

Damage from UV rays breaks down collagen and elastin in the skin, accelerating skin aging.

UV rays can also weaken the skin’s barrier function. This promotes dryness and can also cause spots due to melanin pigment.

As described above, UV damage can also lead to “aging” and “dryness,” so appropriate preventive measures are necessary.

  • Protect the skin every day by taking measures against UV rays, such as using cosmetics
  • Avoid UV rays with hats, parasols, and sunglasses
  • Avoid going outside during times of strong sunlight
  • Use shade when going outside

Effects of Rejuran Under the Eyes

Rejuran is expected to regenerate youthful-looking skin by activating skin cells. What effects can be expected when Rejuran is administered under the eyes?

The following improvements can be expected from the effects of Rejuran.

  • Restore the texture and firmness under the eyes and improve wrinkles, spots, and sagging
  • Improve under-eye dark circles and dullness caused by poor circulation
  • Restore elasticity under the eyes and create a fuller-looking eye area
  • Improve fine wrinkles at the outer corners of the eyes
  • Increase skin moisture and regulate moisture and sebum levels

Rejuran Eye, a Product Suitable for Under-Eye Treatment

There are several types of Rejuran. Among them, Rejuran Eye (Rejuran i) is a product specifically designed to treat the eye area.

Rejuran Eye is formulated for injection into the thin skin around the eyes. Its elasticity and viscosity are lower than those of regular Rejuran, allowing it to blend more easily into the eye area.

Like regular Rejuran, its main beauty ingredient is polynucleotide. It helps improve wrinkles and firmness around the eyes and regenerates the skin, helping create youthful, healthy-looking skin.

How Rejuran Works

Polynucleotide, the main ingredient in Rejuran, is extracted from salmon DNA. Because it is derived from salmon, Rejuran Injection is also referred to as a “high-concentration salmon injection.”

Polynucleotide has a structure similar to human DNA, so it is considered easy for the human body to accept and is associated with a low risk of side effects.

Polynucleotide works in the following ways.

  • Acts on fibroblasts in the dermis to produce collagen, elastin, and hyaluronic acid
  • Promotes skin turnover by regenerating and forming new capillaries and activating them
  • Suppresses skin inflammation through its anti-inflammatory action and improves the skin’s barrier function

How Rejuran Works and Its Effects on Under-Eye Dark Circles

Aging, dryness, and UV rays can cause poor circulation, sagging, and melanin pigmentation, which can lead to under-eye dark circles.

Rejuran works on under-eye dark circles as follows.

  • Promotes blood flow by activating capillaries
  • Improves sagging by producing collagen and elastin
  • Lightens pigmentation by promoting skin turnover

How Rejuran Works and Its Effects on Wrinkles Around the Eyes

When the skin loses firmness and elasticity due to causes such as aging, dryness, and UV rays, wrinkles can develop around the eyes.

Rejuran works on wrinkles around the eyes as follows.

  • Rejuran enhances metabolism and promotes skin turnover, helping produce healthy, moisturized skin
  • Activates fibroblasts to produce collagen, elastin, and hyaluronic acid, restoring skin firmness and elasticity and improving wrinkles

Eye-Area Concerns for Which Rejuran Is Recommended

Rejuran is effective for various eye-area concerns caused by skin deterioration and damage. Here, we introduce the types of eye-related concerns for which Rejuran is recommended.

  • Wrinkles that have developed around the eyes
  • Wrinkles that have developed at the outer corners of the eyes
  • A loss of firmness and radiance around the eyes
  • Under-eye dark circles and dullness
  • Hollowness under the eyes
  • Dryness around the eyes
  • Anti-aging care around the eyes

When Do the Effects of Rejuran Begin?

The effects of Rejuran generally begin to be noticeable after approximately 2–3 weeks.

When Rejuran is administered into the skin, it acts on skin cells to produce collagen and elastin, and promotes blood flow by regenerating and forming new capillaries, thereby producing new cells. It takes time to change the skin from the cellular level in this way.

How Long Do the Effects of Rejuran Last?

The effects of Rejuran last for several months to around six months, although results vary from person to person.

Because Rejuran works on the cells, its effects after acting on the skin cells continue until the cells deteriorate due to factors such as lifestyle habits and individual constitution.

To enhance the effects of Rejuran and experience them more fully, regular treatments are recommended.

Risks and Side Effects of Rejuran

The main ingredient in Rejuran, polynucleotide, has a structure similar to human DNA. Because it resembles substances found in the human body, it is considered easy for the body to accept and is associated with a low risk of side effects and allergic reactions. However, because it is derived from salmon, people with allergies to fish or fish roe are often unable to undergo the treatment.

Because needles are used during the treatment, you may feel some pain. However, pain can be reduced by combining the treatment with topical anesthesia.

After treatment, the areas where Rejuran was administered may swell as though they have been bitten by an insect, but this subsides within several hours to approximately one day. In addition, because needles are used, a tendency to develop bruising may continue for approximately 1–2 weeks.

Give the Under-Eye Area a More Youthful Appearance with Rejuran!

Under-eye dark circles and wrinkles tend to create a gloomy impression of fatigue or aging. Causes of these under-eye dark circles and wrinkles include “age-related decline,” “dryness caused by insufficient skin moisture,” and “damage caused by UV rays.”

Rejuran is highly effective for issues caused by skin deterioration and damage. By activating the skin from the cellular level, Rejuran promotes blood flow and helps regenerate the skin, restoring its texture, firmness, elasticity, and moisture. As a result, under-eye dark circles and wrinkles may improve, giving the eyes a more youthful appearance.

At LIVELY CLINIC, in addition to Rejuran, we also offer Rapunzel Injection, an original injectable treatment combining “high-concentration salmon” and “Micro Botox” with other skin-enhancing ingredients.

Rapunzel Injection is a product based on the effects of the active ingredients in high-concentration salmon to regenerate youthful, firm skin, together with the effects of the active ingredients in Micro Botox to quickly reduce the appearance of pores and suppress sebum production, creating a more refined, translucent complexion.

Rejuran treatment inevitably involves some pain when the product is injected, but Rapunzel Injection has been adjusted to keep pain consistently lower, allowing it to be used around the eyes with reassurance. Rapunzel Injection is also available at a lower price than Rejuran, and is well received by those who wish to continue treatment and experience its effects.

Would you like to learn more about the currently popular Rapunzel Injection? Have you been concerned about under-eye dark circles for many years? Or have you recently begun to notice signs of aging around your eyes and want to care for the area? If so, please feel free to consult us about anything, no matter how minor.

Hydration Injection Price list

Hydration Injection

Moisturizing Hyaluronic Acid
44,000 JPY
Skin Botox
44,000 JPY
Rapunzel Injection (High-Concentration Salmon × Micro Botox)
48,000 JPY
SUNEKOS® Performa
55,000 JPY
Pluryal Densify
66,000 JPY
Rejuran
66,000 JPY
Human Stem Cell Culture Supernatant (Umbilical Cord-Derived)
88,000 JPY

*Hamamatsucho Clinic/Osaka Clinic: Dermashine; Funabashi Clinic: AquaPen

Additional Medication Options

BENEV
9,800 JPY
Tranexamic Acid
9,800 JPY
Click here for details of the Rapunzel Injection treatment menu
Click here to book Rapunzel Injection

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Medically reviewed by

Masao Hayashi

Masao Hayashi

Career

  • 2017 Graduated from Tokyo Medical University
  • 2019 Joined the Department of Otolaryngology-Head and Neck Surgery, Tokyo Medical University
  • 2021 Aesthetic Surgery and Dermatology in Tokyo
  • 2023 THE CLINIC
  • 2024 LIVELY CLINIC