診療科目

Medical Weight Loss Medication (GLP-1)

• TOP
• Menu
• Medical Weight Loss Medication (GLP-1)

Rybelsus and Saxenda were originally developed as medications for diabetes treatment.
However, they have an appetite-suppressing effect and are now also used in medical weight loss.
Through the action of the hormone GLP-1, they help you feel satisfied even with small amounts of food and support better control of food intake.
They make it easier to continue weight loss that was difficult to achieve with exercise and dietary restriction alone.

Recommended for people who

• Those who want to lose weight naturally by suppressing appetite without effort
• Those who repeatedly regain weight after dieting
• Those who find it difficult to manage weight through exercise or dietary restriction alone
• Those who are too busy to maintain a regular lifestyle

• 
• 

What is Rybelsus?

Rybelsus is an oral medication containing the active ingredient semaglutide, a GLP-1 receptor agonist.
It has effects of lowering blood sugar and suppressing appetite.

Appetite-suppressing effect

The greatest feature of Rybelsus is its ability to suppress appetite.
By acting on the brain’s satiety center, it naturally calms appetite and prevents overeating without the need for forced self-control.
As a result, even with reduced food intake, it is easier to feel satisfied, enabling a stress-free diet.
Unlike traditional calorie restriction that relies on strong willpower, Rybelsus works with the body’s natural mechanism to control appetite, which contributes greatly to long-term weight management.

Blood sugar control

Rybelsus slows the absorption of sugar from the intestines, preventing sudden spikes in blood glucose after meals.
This stabilizes insulin secretion and reduces fat storage.
By preventing large fluctuations in blood sugar, it also helps avoid post-meal drowsiness, fatigue, and cravings for snacks.
It not only supports weight loss but also contributes to the prevention and improvement of diabetes and lifestyle-related diseases.

Weight loss with less rebound

Traditional strict dieting or excessive exercise often leads to rebound weight gain.
Rybelsus works on appetite and blood sugar at a fundamental level, enabling sustainable weight control without excessive effort.
Instead of “struggling to lose weight,” it supports a natural process of gradual weight reduction, making it easier to maintain a healthy weight long-term.

Side effects / Risks	Nausea, vomiting, diarrhea, heartburn, dizziness, taste disturbance, indigestion
How to take	Take one tablet once daily in the morning on an empty stomach with up to half a glass of water (≤120ml). Avoid food, drink, or other oral medications for at least 30 minutes afterward. Do not take with tea or liquids other than water.
Contraindications	Pregnant, breastfeeding, or possibly pregnant women / Diabetes / History of pancreatitis / Severe gastrointestinal disorders / History of thyroid disease / Severe renal impairment / History of hypersensitivity to this drug

What is Saxenda?

Saxenda is a GLP-1 receptor agonist administered once daily by subcutaneous injection to support weight management.
It has been widely approved overseas as an obesity treatment and is gaining attention in Japan among people concerned with lifestyle-related diseases and weight gain.
It is particularly appealing because it suppresses appetite naturally and is easier to continue than diets involving strict food restrictions or stress.

Appetite suppression

Saxenda acts directly on the satiety center of the brain to suppress appetite.
It prevents unconscious overeating and snacking, helping patients feel satisfied with smaller meals.
Although injection may cause concern, the pen device uses an ultra-thin needle, making it relatively painless and easy to continue at home.

Blood sugar stability and metabolic improvement

Saxenda prevents rapid increases in blood glucose after meals, reducing fat storage.
It also reduces post-meal sleepiness and sudden hunger, improving snack control.
In addition to weight loss, it may help prevent and improve lifestyle-related diseases such as diabetes and hypertension.

Weight loss with less rebound

Unlike traditional diets that often lead to rebound, Saxenda enables appetite control by working with the body’s mechanism rather than relying on willpower.
This makes it easier to continue and helps stabilize weight in the long run, supporting sustainable dieting.

Difference from Rybelsus

Rybelsus is taken orally, whereas Saxenda is an injectable that delivers a consistent daily dose.
For those comfortable with injections and seeking stable effects, Saxenda may be more suitable.

Side effects / Risks

Nausea, vomiting, loss of appetite, gastric discomfort, fatigue

Contraindications

Pregnant, breastfeeding, or possibly pregnant women / Diabetes / Pancreatitis / Gallstones, cholecystitis / Severe renal or liver impairment / History of major abdominal surgery or bowel obstruction / Eating disorders / BMI <18.5 / Body fat <15% in men or <25% in women / Thyroid disease / Family history of multiple endocrine neoplasia type 2 / Allergy to additives in Saxenda (disodium hydrogen phosphate dihydrate, propylene glycol, phenol)

Price List

Rybelsus

Rybelsus 3mg	11,000JPY / Month
Rybelsus 3mg (3-Month Supply)	9,800JPY / Month
Rybelsus 7mg	22,000JPY / Month
Rybelsus 7mg (3-Month Supply)	19,800JPY / Month
Rybelsus 14mg	36,000JPY / Month
Rybelsus 14mg (3-Month Supply)	29,800JPY / Month

Saxenda

Saxenda (1 Pen)	19,800JPY
Needles and Alcohol Wipes (for Saxenda)	1,100JPY / Month
Saxenda (4 Pens or More, per Pen)	17,600JPY
Saxenda (7 Pens or More, per Pen)	15,600JPY