BLOG

Are There Exosome Therapeutics? Effective Uses and Precautions

Exosomes have attracted considerable attention in the field of beauty for their rejuvenating and skin-beautifying effects, but that is not all. They are also substances that are highly expected to help prevent and treat diseases.

So, are there exosome therapeutics that can help prevent or treat diseases?

Here, we explain the current status of exosome therapeutics, the aspects for which they are expected to be useful, how to obtain exosomes effectively, and what precautions should be taken.

1.Exosomes Are Used in the Field of Beauty
2.Exosome Therapeutics Are Under Research
2-1.Characteristics of Exosomes and Their Expected Effects
2-2.What Is Expected of Exosome Therapeutics
3.The Effects of Exosomes and Ways to Obtain Them
3-1.Effects of Exosomes
3-2.Exosome Treatments and Products Containing Exosomes
3-3.Exosome Drip Therapy Has Significant Effects Throughout the Body
4.Quality Control Is Important When Using Exosomes
4-1.Management Is Important for Exosome Donors, Manufacturing, and Transportation
4-2.Professional Support Is Important for Exosome Treatments

Exosomes Are Used in the Field of Beauty

Exosomes can regenerate and repair skin, blood vessels, and muscles weakened by aging at the cellular level. Because of these effects, research is underway into their use in a range of fields, including regenerative medicine, preventive medicine, and cosmetic medicine.

Among these applications, the effects of exosomes in the field of beauty have attracted particular attention. Administration of exosomes is expected to help rejuvenate weakened skin, improve its appearance, and improve skin quality, drawing interest from people who are highly conscious of their beauty.

In fact, treatments using exosomes are already offered at many cosmetic clinics.

Exosome Therapeutics Are Under Research

Exosomes are also expected to help prevent and treat diseases. However, exosome therapeutics for diseases are still under research, and have not yet been put into practical use.

Exosome research began attracting considerable attention around 2000. At that time, exosomes were found to have a role in transmitting information between cells. This led to expectations for a wide range of applications and increased efforts to research exosome therapeutics.

Characteristics of Exosomes and Their Expected Effects

Exosomes circulate throughout the body carrying information from their original cells and deliver that information to other cells. In addition, they activate cells, helping regenerate and repair weakened cells, as well as attack and eliminate pathogens.

One characteristic of exosomes is that they circulate throughout the body via the bloodstream and act at the cellular level. Therefore, effects can be expected in all types of cells, including those in the skin, blood vessels, bones, muscles, and nerves.

Until now, treatment for diseases has mainly involved suppressing the disease through drug therapy or removing diseased areas through surgery. However, because exosomes act at the cellular level, they are expected to help prevent and treat diseases by targeting cells.

What Is Expected of Exosome Therapeutics

Exosomes are expected to help prevent and improve diseases such as cancer. However, the full nature of exosomes has not yet been elucidated, and there is currently insufficient data to support the research.

Nevertheless, research and development of exosome therapeutics aimed at practical use are underway in Japan and other countries, and some are reportedly entering clinical trials.

If exosome therapeutics are developed, they may be expected to help treat difficult-to-treat diseases such as cancer, collagen diseases, and cirrhosis, so future research will be closely watched.

The Effects of Exosomes and Ways to Obtain Them

So, what is the best way to obtain the effects of exosomes more efficiently?

Effects of Exosomes

Exosomes act on cells, and many effects are expected from them. Let us look at what these effects are.

1. Rejuvenating Effects

Activating weakened cells may help rejuvenate the entire body.

2. Skin-Beautifying Effects and Prevention of Skin Problems

They can improve the skin’s moisturizing capacity and help improve spots and dullness, resulting in more beautiful skin. They also help prevent skin problems by protecting the skin from inflammation and stress caused by ultraviolet rays.

3. Fatigue Recovery, Improved Physical Strength, and Health Promotion

Activating cells throughout the body helps relieve fatigue and supports the development of a body that is less prone to fatigue.

4. Improved Immune Function

They activate immune cells, and improved immune function can be expected.

5. Improvement of Thinning Hair and Hair Loss

They help repair damaged scalp and support hair growth and regrowth.

6. Brain Rejuvenation and Dementia Prevention

Repairing and activating weakened cells in the brain helps prevent a decline in brain function. Preventive effects against brain diseases such as dementia can also be expected.

7. Improved Sleep

By helping relieve fatigue, they improve sleep quality, including how easily you fall asleep and how refreshed you feel upon waking.

8. Effects on Diseases Such as Cancer

Because exosomes may help prevent the metastasis of cancer cells and suppress their growth, they are expected to help treat diseases involving cells.

Exosome Treatments and Products Containing Exosomes

Exosome therapeutics are still under research, but what types of exosome treatments are already being performed, and what products containing exosomes are available?

There are mainly three methods of administering exosomes.

1. Infusion

With infusion, exosomes can be injected directly into the blood vessels, allowing their effects to reach the entire body. For this reason, it is a treatment method expected to provide effects such as rejuvenation, fatigue recovery, and improved immune function throughout the body.

2. Injection

With injection, exosomes can be administered to the areas where effects are desired. It is used for treatments aimed at improving the skin and promoting hair growth, but injections may cause pain, so people who are sensitive to pain should take care.

3. Derma Pen Injection

Derma Pen injection involves using a Derma Pen, which has needles finer than a strand of hair, to create extremely small holes in the skin and inject exosomes through them. This treatment is suitable for improving the overall appearance of facial skin and treating thinning hair by using both the skin-repairing action of the Derma Pen and the effects of exosomes. The procedure can also be performed with little pain.

Cosmetic serums containing exosomes have been developed and are already being sold. However, because cosmetics also contain ingredients that have effects other than those of exosomes, they are not particularly recommended for obtaining the effects of exosomes to the fullest extent.

Exosome Drip Therapy Has Significant Effects Throughout the Body

When you want to experience the effects of exosomes more fully, Exosome Drip Therapy is recommended.

There are several methods of administering exosomes, and you can choose one based on which part of the body you want to treat and what effects you seek. Among these methods, infusion can be considered the way to obtain significant effects throughout the body.

Exosomes can also be incorporated through cosmetics, but because they must be absorbed through the skin, it takes longer to produce effects than infusion, which delivers them directly into the bloodstream.

Quality Control Is Important When Using Exosomes

Because exosomes act on cells, they are expected to become a treatment method applicable to many areas throughout the body, and research is continuing.

Exosomes used in treatment are cultured from human-derived cells. Although their effects vary depending on the cells used for culturing, exosomes are generally considered safe because they are substances that naturally exist in the body.

However, not all exosomes can be used safely and provide effects. Because human-derived cells are cultured, the exosomes may be affected by the donor’s health and the conditions under which the exosomes are managed. Therefore, quality control requires careful attention to ensure the safe use of exosomes.

Management Is Important for Exosome Donors, Manufacturing, and Transportation

Currently, the quality of exosomes in circulation varies. To receive exosomes that are safe and of high quality, it is necessary to visit a clinic that provides exosomes subject to thorough quality control.

First, donors are important for exosome quality control. Exosomes are produced by culturing stem cells. Therefore, it is important to manage the donors who provide the stem cells. The donor’s nationality, sex, age, blood test results, and other information must be carefully checked, and exosomes must be manufactured from stem cells that have passed these checks.

Thorough management is also necessary for manufacturing and transportation. Special technologies are required to manufacture high-quality exosomes. Therefore, they must be manufactured at a government-approved cell processing facility and transported under conditions that prevent any loss of quality.

Professional Support Is Important for Exosome Treatments

In addition to high-quality exosomes, professional support is essential for exosome treatments. To support not only exosome management but also the health management of people receiving treatment, thorough support is needed, from pre-treatment counseling and plan development through treatment and follow-up afterward. Receiving treatment using high-quality exosomes with professional support makes it possible to obtain the effects of exosomes.

Exosome Therapeutics Are Under Development but Hold Potential

Exosome therapeutics are under development, and research is still underway. Although they have not yet been put into practical use, exosome therapeutics, which act on cells, are expected to be effective for difficult-to-treat diseases such as cancer, collagen diseases, and cirrhosis.
Exosome Drip Therapy is recommended among the exosome applications currently in practical use, as it can provide significant effects throughout the body.

However, effects vary depending on the quality of the exosomes. To obtain the desired effects, thorough quality control is necessary at every stage, from the donor of the stem cells from which the exosomes originate through manufacturing, transportation, and treatment.

At LIVELY CLINIC, we use exosomes cultured from Japanese donors. The cell processing facility that manufactures the exosomes has received government approval and produces the highest-quality products under safe, controlled conditions. Specialized exosome staff are also on site, so you can feel reassured.

If you are interested in the effects of exosomes and would like to try them, or if you would like to know whether exosomes may help address your concerns, please feel free to contact us about anything, no matter how minor.

Click here for details of the Exosome Drip Therapy treatment menu

Click here to book Exosome Drip Therapy

Medically reviewed by

Masao Hayashi

Career

2017 Graduated from Tokyo Medical University
2019 Joined the Department of Otolaryngology-Head and Neck Surgery, Tokyo Medical University
2021 Aesthetic Surgery and Dermatology in Tokyo
2023 THE CLINIC
2024 LIVELY CLINIC