BLOG

Drip Therapies for Rejuvenation! Explaining the Difference Between Exosomes and NMN

Exosome Drip Therapy and NMN Drip are attracting attention among people interested in beauty because they can deliver essential components directly to the body.

Even if you know that these therapies may have rejuvenating effects, you may not know how exosomes and NMN differ.

Here, we will explain in detail the characteristics and differences between exosomes and NMN, two representative therapies that may have rejuvenating effects.

1.Drip therapies with rejuvenating effects are attracting attention
2.What are exosomes?
2-1.The difference between exosomes and stem cell culture supernatant
2-2.Exosomes transmit information between cells
2-3.Potential effects of exosomes
2-4.The effects of exosomes vary according to their components and quality
2-5.Cost and treatment schedule for Exosome Drip Therapy
3.What is NMN?
3-1.NMN is converted into NAD+ in the body, where it takes effect
3-2.NMN can be taken as a supplement
3-3.NAD+ activates the sirtuin genes
3-4.Potential effects of NAD+
3-5.Cost and treatment schedule for NMN Drip
4.The difference between exosomes and NMN
4-1.Their effects may be similar, but their mechanisms differ
4-2.Exosome Drip Therapy is recommended for activating cells throughout the body

Drip therapies with rejuvenating effects are attracting attention

Drip therapy is a treatment aimed at improving symptoms that have appeared in the body and promoting health by administering beneficial components directly into a vein through an intravenous drip.

美容医療 involving drip therapy to administer components that may rejuvenate the skin and blood vessels and improve the skin's appearance is attracting attention, and these treatments are offered at various cosmetic clinics.

The advantage of drip therapy is that administering beneficial components directly into the bloodstream can deliver their effects throughout the body more efficiently. This is difficult to achieve through oral intake, such as supplements, which is why drip therapy is popular among people who are highly interested in beauty and want to experience greater effects.

What are exosomes?

Let us look at what exosomes are and what effects they may have when administered through drip therapy for rejuvenation and skin improvement.

The difference between exosomes and stem cell culture supernatant

Exosomes and stem cell culture supernatant are sometimes described as if they were the same thing, but they are different.

First, Exosome Drip Therapy uses stem cell culture supernatant. Stem cell culture supernatant is the liquid collected from the supernatant of a culture in which human-derived stem cells have been grown. Impurities are removed, and beneficial components for the body are concentrated. Exosomes are one of the components found in high concentrations in this liquid.

Exosomes transmit information between cells

Exosomes are extremely small substances approximately 30–150 nm in diameter that are secreted by cells. They exist throughout the body, and their primary function is to transmit information between cells.

Exosomes contain mRNA (messenger RNA), microRNA, proteins, and other substances. They travel throughout the body and are thought to convey information from the source cell to the target cell by delivering their contents to cells.

The information transmitted by exosomes also varies according to the characteristics of the source cell. For example, exosomes originating from cancer cells have been found to exhibit characteristics not seen in exosomes from healthy cells. Further research is still needed to apply these characteristics.

Potential effects of exosomes

When information transmission by exosomes occurs frequently, old cells are replaced by new cells, helping the body remain youthful and healthy. On the other hand, when information transmission decreases, cell turnover also declines, leading to signs of aging such as loss of skin texture and firmness and persistent fatigue.

What effects can be expected from exosomes?

Rejuvenating effects
Improved skin appearance and skin quality
Improved physical stamina
Fatigue recovery
Health promotion
Improved immune function
Improved sleep
Dementia prevention
Improvement of thinning hair and hair loss

As described above, incorporating exosomes into the body may have benefits for beauty and health.

The effects of exosomes vary according to their components and quality

Exosomes function to transmit information between cells. The components of the stem cell culture supernatant used in Exosome Drip Therapy vary according to the stem cells used for culturing, and the effects also vary accordingly. Among the various types, including those derived from adipose tissue, dental pulp, and umbilical cords, umbilical cord-derived products are expected to have the greatest rejuvenating effects.

The components and quality also differ depending on the handling processes, management, and manufacturer. To obtain significant effects from Exosome Drip Therapy, treatment should use high-purity exosomes from Japanese stem cell donors that have been safely managed at a facility approved by the national government, with impurities removed.

Cost and treatment schedule for Exosome Drip Therapy

The cost of Exosome Drip Therapy typically ranges widely from 5 to 20万円. This difference is due to the components of the exosomes and the amount of exosomes they contain.

Each treatment takes approximately 30 minutes. We recommend receiving treatment once every 2 weeks to 1 month for about 5 sessions, followed by maintenance treatment once every 6 months to 1 year. Many people typically begin to notice effects within 2 weeks to 1 month, while some people notice them within a few days.

What is NMN?

Next, let us look at what NMN is and what effects it may have.

NMN is converted into NAD+ in the body, where it takes effect

NMN Drip is one of the drip therapies that may have rejuvenating effects. When NMN (nicotinamide mononucleotide vitamin) is absorbed into the body, it is converted into a substance called NAD+ (nicotinamide adenine dinucleotide). NAD+ is involved in producing the energy humans need, rejuvenation, maintaining health, and dementia prevention, and it has been reported to potentially improve age-related signs of aging.

Both NMN and NAD+ are substances that naturally exist in the body. NMN is produced in the body, but its production decreases with age. As a result, NAD+ also decreases, which is thought to contribute to the progression of aging.

For this reason, drip therapy that directly administers NMN, a precursor of NAD+, into the bloodstream is attracting attention. There is also NAD+ Drip, which administers NAD+ directly. Because conversion from NMN to NAD+ is not necessary, it is considered easier to obtain effects.

NMN can be taken as a supplement

How can NAD+ be increased? NAD+, which may provide rejuvenating effects, cannot be taken orally.

However, NMN, a precursor of NAD+, can be obtained from food. It is found in foods such as broccoli and edamame. While the amount of NMN needed per day is approximately 100–200㎎, obtaining NMN from broccoli would require eating several thousand florets. The same applies to other foods, and obtaining the necessary amount of NMN from food would require an unrealistic quantity.

Using supplements containing concentrated NMN therefore makes efficient oral intake possible.

Drip therapy is recommended when you want to act directly on the body, while using supplements as part of self-care may help you expect greater effects.

NAD+ activates the sirtuin genes

NAD+ functions to activate the sirtuin genes. The sirtuin genes are also called “longevity genes” and promote cellular rejuvenation and regulate aging.

Activation of the sirtuin genes activates the mitochondria that produce energy in the body. This increases basal metabolism and may make the body less susceptible to illness. In addition, sirtuin genes protect telomeres and help prevent them from becoming shorter, thereby helping extend the lifespan of cells. Telomeres become shorter as cells divide, and once they reach a certain length, cell division no longer occurs.

As described above, when NAD+ activates the sirtuin genes, energy is produced and cell lifespan can be extended. This may help improve various age-related changes.

Potential effects of NAD+

Humans need energy to remain active. The sirtuin genes are needed to activate the mitochondria that produce this energy, and NAD+ is needed to activate the sirtuin genes.

Therefore, administering NMN, a precursor of NAD+, may provide the following effects.

Rejuvenating effects
Improved skin quality
Health promotion
Increased muscle mass
Suppression of obesity
Improved metabolism
Improved sleep
Improved mitochondrial function

Cost and treatment schedule for NMN Drip

The cost of NMN Drip containing 100㎎ of NMN is typically around 3～5万円.

Each treatment takes approximately 30 minutes. We recommend continuing treatment once every 2 weeks to 1 month. Effects are said to become noticeable after continuing treatment for approximately 3–6 months.

The difference between exosomes and NMN

We have explained exosomes and NMN above. So, how do exosomes and NMN differ?

Their effects may be similar, but their mechanisms differ

Exosomes and NMN have similar effects, such as rejuvenation and improved skin quality. However, their mechanisms are completely different.

Exosomes act on weakened cells and promote the regeneration and repair of weakened skin, muscles, blood vessels, and nerve cells, activating the entire body at the cellular level. NMN, on the other hand, aims to improve vital functions by providing the nutrients cells need to produce energy.

Thus, both activate bodily functions that have declined with aging, but their mechanisms for rejuvenation differ.

Exosome Drip Therapy is recommended for activating cells throughout the body

When undergoing drip therapy for rejuvenation, Exosome Drip Therapy is recommended if you want to target cells throughout the body, including not only the skin but also the muscles and blood vessels. This is because exosomes act on weakened cells and can flow through the body from the bloodstream to act on cells throughout the body.

There is also a difference in the age at which effects are generally expected to appear. Exosomes are generally considered to have effects from a person's 30s, while NMN is said to have effects from a person's 40s. You should consider the appropriate option based on your individual condition and the effects you seek.

LIVELY CLINIC's commitment to exosomes

The effects of Exosome Drip Therapy can vary greatly depending on the components and quality of the medication used. Therefore, please make sure that the exosomes being administered are of high quality.

LIVELY CLINIC uses Wharton's jelly (umbilical cord-derived), which accounts for less than 1% of exosomes distributed domestically. It is obtained from a baby's umbilical cord and is expected to have significant rejuvenating effects.

For safety, we also use the highest-quality product cultured from stem cells donated by Japanese donors and manufactured at a cell-processing facility approved by the national government.

Because the treatment is not covered by insurance, the cost is inevitably relatively high. However, we also offer course discounts to make treatment more affordable for continued visits.

If you are concerned about a decline in your skin quality or physical stamina, would like to learn more about the effects of exosomes, or are considering exosome treatment but hesitant due to concerns about the cost, please feel free to consult us about anything, no matter how minor.

Click here for details of the Exosome Drip Therapy treatment menu

Click here to book Exosome Drip Therapy